Is Hydroxychloroquine a possible post-exposure prophylaxis drug to limit the transmission to health care workers exposed to COVID19? / Pagliano, P. (et al). Accepted manuscript. Clinical Infectious Diseases. 24 March 2020. (note link downloads a PDF).
NIH Panel Recommends Against Drug Combination Trump Has Promoted For COVID-19
A panel of experts convened by the National Institute of Allergy and Infectious Diseases recommends against doctors using a combination of hydroxychloroquine and azithromycin for the treatment of COVID-19 patients because of potential toxicities. "The combination of hydroxychloroquine and azithromycin was associated with QTc prolongation in patients with COVID-19," the panel said. QTc prolongation increases the risk of sudden cardiac death.
QT prolongation, torsades de pointes and sudden death with short course of chloroquine or hydoxychloroquine as used in COVID-19: a systematic review / Lior Jankelson (et al). Heart Rhythm 10 May 2020.
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